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  • Phenoxodiol
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Phenoxodiol

A phenol with anticancer activity

原价
¥2287-3775
价格
1830-3020
Phenoxodiol的二维码

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  • 货号: ajce58032
  • CAS: 81267-65-4
  • 别名: 脱氢雌马酚,Idronoxil; Dehydroequol; Haginin E
  • 分子式: C15H12O3
  • 分子量: 240.25
  • 纯度: >98%
  • 溶解度: DMSO: ≥ 100 mg/mL (416.23 mM); Water: < 0.1 mg/mL (insoluble)
  • 储存: Store at -20°C
  • 库存: 现货

Background

Idronoxil is a phenol and derivative of genistein that has been found in B. tournefortii and has anticancer activity.1,2,3 It reduces the viability of R182S, R127, Hey, CP70, A2780, R187, R188, and R207 primary ovarian cancer cells, but not non-cancerous ovarian surface epithelial (OSE) cells, when used at a concentration of 10 ?g/ml.2 Idronoxil (1 ?g/ml) reduces colony formation and induces apoptosis in R127 and CP70 primary ovarian cancer cells, respectively, and restores sensitivity to Fas-mediated apoptosis in CP70 cells. In vivo, idronoxil (50 and 75 mg/kg) increases latency to tumor formation and reduces tumor multiplicity in a rat model of mammary carcinogenesis induced by dimethylbenz[a]anthracene (DMBA).3


1.Rahmani, R., Bouajila, J., Jouaidi, M., et al.African mustard (Brassica tournefortii) as source of nutrients and nutraceuticals propertiesJ. Food Sci.85(6)1856-1871(2020) 2.Kamsteeg, M., Rutherford, T., Sapi, E., et al.Phenoxodiol – an isoflavone analog – induces apoptosis in chemoresistant ovarian cancer cellsOncogene22(17)2611-2620(2003) 3.Constantinou, A.I., Mehta, R., and Husband, A.Phenoxodiol, a novel isoflavone derivative, inhibits dimethylbenz[a]anthracene (DMBA)-induced mammary carcinogenesis in female Sprague–Dawley ratsEur. J. Cancer39(7)1012-1018(2004)

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