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  • Piperaquine tetraphosphate tetrahydrate
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Piperaquine tetraphosphate tetrahydrate

An antimalarial agent

价格
0-2440
Piperaquine tetraphosphate tetrahydrate的二维码

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  • 货号: ajce58092
  • CAS: 915967-82-7
  • 别名: 四磷酸哌喹四水合物
  • 分子式: C29H32Cl2N6.4H3O4P.4H2O
  • 分子量: 999.6
  • 纯度: >98%
  • 溶解度: Water: 6 mg/mL (6.00 mM); DMSO: < 1 mg/mL (insoluble or slightly soluble)
  • 储存: Store at -20°C
  • 库存: 现货

Background

Piperaquine is a bis-quinoline compound that inhibits the ex vivo growth of P. falciparum isolates from malaria-infected patients with IC50s ranging from 11.8-217.3 nM.1 Formulations containing piperaquine have been used in combination with artemisinin for the treatment of malaria in HIV-1-positive populations.2,3,4


1.Akoachere, M., Buchholz, K., Fischer, E., et al.In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisininsAntimicrob. Agents Chemother.49(11)4592-4597(2005) 2.Askling, H.H., Bruneel, F., Burchard, G., et al.Management of imported malaria in EuropeMalar. J.11(2012) 3.Henrich, P.P., O'Brien, C., Sáenz, F.E., et al.Evidence for pyronaridine as a highly effective partner drug for treatment of artemisinin-resistant malaria in a rodent modelAntimicrob. Agents Chemother.58(1)183-195(2014) 4.Pascual, A., Parola, P., Benoit-Vical, F., et al.Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparumMalar. J.11(2012)

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