PP7

PP7 是一种PB1-PB2 互作抑制剂，IC50 值为 8.6 μM。PB1-PB2 抑制影响病毒聚合酶的活性(IC50=9.5 μM)。PP7 对甲型流感病毒 A (IAV) 包括 (H1N1)pdm09 (EC50=1.4 μM)，A(H7N9)，A(H9N2) 亚型具有抗病毒活性。

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Background

PP7 is a potent PB1-PB2 interaction inhibitor with an IC50 of 8.6 μM, and their inhibition against viral polymerase activity (IC50=9.5 μM). PP7 shows antiviral activities against influenza A virus (IAV), including A(H1N1)pdm09 (EC50=1.4 μM), A(H7N9) and A(H9N2) subtypes[1]. IC50: 8.6 μM (PB1-PB2 interaction)[1]

[1]. Yuan S, et al. Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface. Antiviral Res. 2017 Jan;137:58-66.