PSI-7976

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10mg

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0.00

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50mg

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1mg

￥4645.00

4180.00

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5mg

￥34965.00

31468.00

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PSI-7976是PSI-7977的同分异构体，能抑制HCV RNA复制，EC50为1.07uM。

货号：ajce58306
CAS：1190308-01-0
分子式：C22H29FN3O9P
分子量：529.45
纯度：98%
存储：Store at -20°C
库存：现货

Background:

PSI-7976 is the isomer of PSI-7977. PSI-7977 is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.

PSI-7851 is a mixture of two diastereoisomers, PSI-7976 and PSI-7977, with PSI-7977 being the more active inhibitor of HCV RNA replication in the HCV replicon assay. Carboxylesterase 1 (CES1) preferentially hydrolyzes PSI-7976 over PSI-7977. The kinetic data also indicates that PSI-7976 is a better substrate for CES1 than for cathepsin A (CatA)[1]

[1]. Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285(45):34337-47.