PSI-7976
PSI-7976是PSI-7977的同分异构体，能抑制HCV RNA复制，EC50为1.07uM。
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包装价格促销价数量
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10mg￥0.000.00- +
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50mg￥0.000.00- +
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1mg￥4645.004180.00- +
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5mg￥34965.0031468.00- +
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- 货号: ajce58306
- CAS: 1190308-01-0
- 别名: 索非布韦R-磷酸盐
- 分子式: C22H29FN3O9P
- 分子量: 529.45
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
PSI-7976 is the isomer of PSI-7977. PSI-7977 is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
PSI-7851 is a mixture of two diastereoisomers, PSI-7976 and PSI-7977, with PSI-7977 being the more active inhibitor of HCV RNA replication in the HCV replicon assay. Carboxylesterase 1 (CES1) preferentially hydrolyzes PSI-7976 over PSI-7977. The kinetic data also indicates that PSI-7976 is a better substrate for CES1 than for cathepsin A (CatA)[1]
[1]. Murakami E, et al. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. J Biol Chem. 2010 Nov 5;285(45):34337-47.
