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  • Swertisin
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Swertisin

A flavonoid C-glycoside with diverse biological activities

原价
¥2487-7400
价格
1990-5920
Swertisin的二维码

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  • 货号: ajce59658
  • CAS: 6991-10-2
  • 别名: 当药黄素
  • 分子式: C22H22O10
  • 分子量: 446.4
  • 纯度: >98%
  • 溶解度: Soluble in DMSO
  • 储存: Store at -20°C
  • 库存: 现货

Background

Swertisin is a flavonoid C-glycoside that has been found in Swertia japonica and has diverse biological activities.1,2,3 It inhibits sodium-glucose cotransporter 2 (SGLT2) in HEK293 cells when used at a concentration of 7.5 ?g/ml and is an adenosine A1 receptor antagonist (IC50 = 137 ?M).1,2 Swertisin (0.2-5 ?M) inhibits hepatitis B virus (HBV) replication in HepG2 2.2.15 cells.3 It decreases blood glucose levels in a mouse model of diabetes induced by streptozotocin , as well as prevents scopolamine-induced increases in escape latency in the Morris water maze in mice.1,2


1.Bhardwaj, G., Vakani, M., Srivastava, A., et al.Swertisin, a novel SGLT2 inhibitor, with improved glucose homeostasis for effective diabetes therapyArch. Biochem. Biophys.710108995(2021) 2.Lee, H.E., Jeon, S.J., Ryu, B., et al.Swertisin, a C-glucosylflavone, ameliorates scopolamine-induced memory impairment in mice with its adenosine A1 receptor antagonistic propertyBehav. Brain Res.306137-145(2016) 3.Xu, H.-Y., Ren, J.-H., Su, Y., et al.Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum MaximJ. Ethnopharmacol.257112787(2020)

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