Tenovin-6 Hydrochloride

A small molecule activator of p53

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2mg

￥1087.00

870.00

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5mg

￥2500.00

2000.00

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10mg

￥3887.00

3110.00

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50mg

￥10687.00

8550.00

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100mg

￥18700.00

14960.00

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200mg

￥0.00

0.00

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500mg

￥0.00

0.00

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Background

The tumor suppressor function of p53 hinges on its ability to function as a transcription factor. Tenovin-6 is an analog of tenovin-1, a small molecule activator of p53 transcriptional activity. At 10 ?M, this compound is slightly more effective than tenovin-1 at elevating p53 activity in MCF-7 cells and reduces growth of ARN8 melanoma xenograft tumors in SCID mice at a dose of 50 mg/kg.¹ Tenovin-6 inhibits the protein deacetylase activities of purified human SIRT1, SIRT2, and SIRT3 in vitro with IC₅₀ values of 21, 10, and 67 ?M, respectively.¹

1.Lain, S., Hollick, J.J., Campbell, J., et al.Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activatorCancer Cell13(5)454-463(2008)