现货大促销,价格低至8折起,量大更优惠,详细咨询客服
全部分类
全部分类
  • Tucidinostat
Tucidinostat的可视化放大

Tucidinostat

An HDAC inhibitor

原价
¥600-4275
价格
480-3420
Tucidinostat的二维码

所有产品仅用于科学研究,我们不为任何个人用途提供产品和服务

询价有惊喜,量大更优惠 点击这里给我发消息

  • 库存: 现货
可选包装 >>>
首页
  • 货号: ajce59932
  • CAS: 1616493-44-7
  • 别名: 西达本胺; Chidamide; HBI-8000; CS 055
  • 分子式: C22H19FN4O2
  • 分子量: 390.41
  • 纯度: >98%
  • 溶解度: DMSO: ≥ 50 mg/mL (128.07 mM)
  • 储存: Store at -20°C
  • 库存: 现货

Background

Chidamide is an inhibitor of histone deacetylases (HDACs; IC50s = 0.095, 0.160, 0.067, 0.733, 0.078, and 0.432 ?M for HDAC1-3, 8, 10, and 11, respectively).1 It is selective for these HDACs over HDAC4-7 and 9 (IC50s = >30 ?M for all). Chidamide also inhibits nicotinamide phosphoribosyltransferase (Nampt; IC50 = 2.1 ?M).2 It inhibits cell growth in a panel of 18 cancer cell lines (GI50s = 0.4-40 ?M) but has no effect on the growth of non-cancerous CCC-HEK human fetal kidney or CCC-HEL human liver cells (GI50s = >100 ?M).1 In vivo, tucidinostat (12.5, 25, and 50 mg/kg) reduces tumor growth in HCT-8, A549, BEL-7402, and MCF-7 mouse xenograft models.1


1.Ning, Z.-Q., Li, Z.-B., Newman, M.J., et al.Chidamide (CS055/HBI-8000): A new histone deacetylase inhibitor of the benzamide class with antitumor activity and the ability to enhance immune cell-mediated tumor cell cytotoxicityCancer Chemother. Pharmacol.69(4)901-909(2012) 2.Wu, Y., Wang, L., Huang, Y., et al.Nicotinamide phosphoribosyltransferase (NAMPT) is a new target of antitumor agent chidamideACS Med. Chem. Lett.11(1)40-44(2020)

动态评分

0.0

没有评分数据
没有评价数据
一键回到顶部
展开 收缩
安捷凯在线客服