Verproside，一种从 Pseudolysimachion 属分离的梓醇衍生物环烯醚萜苷，通过 IKK/IκB 信号级联反应抑制 NF-κB 活化，抑制TNF-α 诱导的 MUC5AC 表达。Verproside具有有效的抗炎，抗氧化，抗伤害作用，并且在体内是一种有效的抗哮喘 /COPD 候选药物。
Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive activities and ir is a potent anti-asthmatic/COPD drug candidate in vivo[1]. NF-κB TNF-α IKK
Verproside (2.5-20 μM; for 2 hours) markedly reduces phosphorylation levels of IKKα/β, IκBα, and TAK1 in the 5-20 μM range[1]. Western Blot Analysis[1] Cell Line: NCI-H292 cells
Verproside (Intragastrically; 30 mg/kg; 48 hours) significantly reduces the immunoglobulin E (IgE) levels of verproside-treated mice[2]. Animal Model: Specific pathogen-free female BALB/c mice aged 8-10 weeks[2]
[1]. Lee SU, et al. Verproside inhibits TNF-α-induced MUC5AC expression through suppression of the TNF-α/NF-κB pathway in human airway epithelial cells. Cytokine. 2016 Jan;77:168-75. [2]. Oh SR, et al. Suppressive effect of verproside isolated from Pseudolysimachion longifolium on airway inflammation in a mouse model of allergic asthma. Int Immunopharmacol. 2006 Jun;6(6):978-86. Epub 2006 Feb 10.
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