Voxilaprevir

A pan-genotypic HCV NS3/4A protease inhibitor

此产品仅用于科学研究，我们不为任何个人用途提供产品和服务

库存: 现货

可选规格

包装

价格

促销价

数量
5mg

￥5175.00

4140.00

- +
10mg

￥9175.00

7340.00

- +

已选 0 种 0 瓶

金额: ￥0.00

首页收藏

Background

Voxilaprevir is a pan-genotypic hepatitis C virus (HCV) non-structural 3/4A (NS3/4A) serine protease inhibitor.¹ It inhibits replication of wild-type HCV genotypes 1a, 1b, 2a, 2b, 3a, 4a, 5a, and 6a (EC₅₀s = 1.9-6.6 nM in replicon assays). Voxilaprevir also inhibits replication of mutant HCV genotypes containing NS3 resistance-associated substitutions (EC₅₀s = 3.1, 2.7, and 4 nM for HCV genotypes 1a Q80K, 1a R155K, and 1b D168E, respectively). Formulations containing voxilaprevir have been used in the treatment of chronic HCV infection.

1.Taylor, J.G., Zipfel, S., Ramey, K., et al.Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi?Bioorg. Med. Chem. Lett.29(16)2428-2436(2019)