A sesquiterpene alkaloid with paralytic activity
Wilforgine is a sesquiterpene alkaloid that has been found in T. wilfordii and has paralytic activity.1,2 It induces paralysis in third instar M. separata larvae with a 50% narcotic concentration (NC50) value of 0.0086 ?mol/larvae.2
1.Ouyang, X.-K., Jin, M.-C., and He, C.-H.Simultaneous determination of four sesquiterpene alkaloids in Tripterygium wilfordii Hook. F. extracts by high-performance liquid chromatographyPhytochem. Anal.18(4)320-325(2007) 2.Qu, H., Lv, M., Yu, X., et al.Discovery of some piperine-based phenylsulfonylhydrazone derivatives as potent botanically narcotic agentsSci. Rep.513077(2015)
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