A triterpene saponin and an active metabolite of ginsenoside Ro
Zingibroside R1 is a triterpene saponin and an active metabolite of ginsenoside Ro that has been found in P. japonicus.1,2 It is cytotoxic to B16/F10 murine melanoma cells (IC50 = 24.52 ?g/ml) and inhibits tube formation by human umbilical vein endothelial cells (HUVECs) when used at a concentration of 40 ?g/ml. Zingibroside R1 (25 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model.
1.Yoshizaki, K., Devkota, H.P., Fujino, H., et al.Saponins composition of rhizomes, taproots, and lateral roots of Satsuma-ninjin (Panax japonicus)Chem. Pharm. Bull. (Tokyo)61(3)344-350(2013) 2.Zheng, S.-W., Xiao, S.-Y., Wang, J., et al.Inhibitory effects of ginsenoside ro on the growth of B16F10 melanoma via its metabolitesMolecules24(16)2985(2019)
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