A sesquiterpenoid with anticancer activity
Dendrobine is a sesquiterpenoid that has been found in D. nobile and has anticancer activity.1,2 It decreases viability of A549 cells when used at concentrations ranging from 2.5 to 15 ?g/ml.2 It induces apoptosis in A549 cells when used at concentrations ranging from 1 to 10 ?g/ml, as well as increases JNK phosphorylation and sensitizes A549 cells to cisplatin at 10 ?g/ml. Dendrobine (50 mg/kg per day) reduces tumor growth in an A549 mouse xenograft model with an additive effect when used in combination with cisplatin.
1.Meng, C.-W., He, Y.-L., Peng, C., et al.Picrotoxane sesquiterpenoids from the stems of Dendrobium nobile and their absolute configurations and angiogenesis effectFitoterapia121206-211(2017) 2.Song, T.-H., Chen, X.-X., Lee, C.K.-F., et al.Dendrobine targeting JNK stress signaling to sensitize chemotoxicity of cisplatin against non-small cell lung cancer cells in vitro and in vivoPhytomedicine5318-27(2019)
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