Background:
Morin hydrate is a plant flavonoid extracted from yellow Brazil wood with anti-oxidant properties. Previous studies have shown that morin hydrate could protect cells against oxygen radical damage.
In vitro: Morin hydrate at 75-100 μM protected against the oxidation of low density lipoprotein (LDL) induced by free radicals [1]. Morin hydrate at 100 μM concentration effectively inhibited Cu2+-induced oxidation of human LDL [2]. In cultured rat glomerular mesangial cells attacked by oxyradicals, the survival time of the cells was doubled with using morin hydrate [3]. 0.25 – 2.0 mM morin prolonged the survival of rat hepatocytes against free radical damage triggered by xanthine oxidase-hypoxanthine [4]. Morin hydrate could inhibit the amyloid formation by islet amyloid polypeptide and disaggregated amyloid fibers [5].
In vivo: In a 80 min ischemia rat model, treatment of morin at 2.5, 5.0 and 10 μmol/Kg reduced liver necrosis by 51.48 ± 9.94%, 66.55 ± 2.18%, and 79.37 ± 11.03%, respectively [3].
参考文献:
[1].Wu T W, Fung K P, Wu J, et al.? Morin hydrate inhibits azo-initiator induced oxidation of human low density lipoprotein[J]. Life sciences, 1995, 58(2): PL17-PL22.
[2].Wu T W, Fung K P, Yang C C, et al.? Antioxidation of human low density lipoprotein by horin hydrate[J]. Life sciences, 1995, 57(3): PL51-PL56.
[3].Zeng L H, Fung K P, Wu T W.? Morin hydrate protects cultured rat glomerular mesangial cells against oxyradical damage[J]. Life sciences, 1994, 55(18): PL351-PL357.
[4].Wu T W, Zeng L H, Wu J, et al.? Morin hydrate is a plant-derived and antioxidant-based hepatoprotector[J]. Life sciences, 1993, 53(13): PL213-PL218.
[5].Noor H, Cao P, Raleigh D P.? Morin hydrate inhibits amyloid formation by islet amyloid polypeptide and disaggregates amyloid fibers[J]. Protein Science, 2012, 21(3): 373-382.
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