A natural flavonoid and antioxidant
Quercetin is an antioxidant flavonoid compound found in many plants and fruits.1 Quercetin 3-D-galactoside, commonly known as hyperoside, is a 3-O-galactoside of quercetin that can be found in a wide range of plants.2,3 It has powerful antioxidant action through its ability to scavenge free radicals (IC50s = 3.54 and 5.44 ?g/ml in ABTS and DPPH assays, respectively).2,4,5 Quercetin 3-D-galactoside downregulates the advanced glycation end-product (AGE) receptor in AGE-stimulated ECV304 cells and stimulates osteogenic differentiation of human osteosarcoma cells.6,7
1.Gschwendt, M., Horn, F., Kittstein, W., et al.Inhibition of the calcium- and phospholipid-dependent protein kinase activity from mouse brain cytosol by quercetinBiochem. Biophys. Res. Commun.117(2)444-447(1983) 2.Bernatoniene, J., Masteikova, R., Majine, D., et al.Free radical-scavenging activities of Crataegus monogyna extractsMedicina (Kaunas)44(9)706-712(2008) 3.Jurikova, T., Sochor, J., Rop, O., et al.Polyphenolic profile and biological activity of Chinese hawthorn (Crataegus pinnatifida BUNGE) fruitsMolecules17(12)14490-14509(2012) 4.Lee, K.J., Oh, Y.C., Cho, W.K., et al.Antioxidant and anti-inflammatory activity determination of one hundred kinds of pure chemical compounds using offline and online screening HPLC assayEvid. Based Complement. Alternat. Med.165457(2015) 5.Chen, J.W., Zhu, Z.Q., Hu, T.X., et al.Structure-activity relationship of natural flavonoids in hydroxyl radical-scavenging effectsActa Pharmacol. Sin.23(7)667-672(2002) 6.Zhang, Z., Sethiel, M.S., Shen, W., et al.Hyperoside downregulates the receptor for advanced glycation end products (RAGE) and promotes proliferation in ECV304 cells via the c-Jun N-terminal kinases (JNK) pathway following stimulation by advanced glycation end-products in vitroInt. J. Mol. Sci.14(11)22697-22707(2013) 7.Zhang, N., Ying, M.D., Wu, Y.P., et al.Hyperoside, a flavonoid compound, inhibits proliferation and stimulates osteogenic differentiation of human osteosarcoma cellsPLoS One9(7)(2014)
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