A flavonoid with anticancer and vasorelaxant activities
Trifolirhizin is a flavonoid that has been found in S. flavescens and has anticancer and vasorelaxant activities.1,2 It induces the accumulation of LC3 puncta, a marker of autophagy, in HCT116 and SW620 cells, as well as inhibits proliferation of B16/F10 murine melanoma and human A2780 ovarian and MKN45 gastric cancer cells when used at a concentration of 20 ?M.1 Trifolirhizin (10 m/kg) induces intratumor apoptosis and necrosis and reduces tumor weight and volume in a colorectal cancer mouse xenograft model. It also induces relaxation in precontracted isolated mouse aortic rings in a β2-adrenergic receptor-independent manner when used at concentrations ranging from 0.2 to 20 ?g/ml.2
1.Sun, D., Tao, W., Zhang, F., et al.Trifolirhizin induces autophagy-dependent apoptosis in colon cancer via AMPK/mTOR signalingSignal Transduct. Target. Ther.5(1)174(2020) 2.Yang, N., Liang, B., Srivastava, K., et al.The Sophora flavescens flavonoid compound trifolirhizin inhibits acetylcholine induced airway smooth muscle contractionPhytochemistry95259-267(2013)
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