A steroidal saponin with diverse biological activities
Disogluside is a steroidal saponin that has been found in T. tschonoskii and has diverse biological activities.1,2,3,4,5 It is an inhibitor of UDP-glucuronosyltransferase (UGT) isoform UGT1A4 (IC50 = 10.5 ?M).1 Disogluside is cytotoxic to K562 chronic myeloid leukemia (CML) cells (IC50 = ~7.5 ?M).2 It improves neurological function and decreases neuronal damage in a rat model of spinal cord injury when administered at a dose of 100 mg/kg.3 Disogluside (50 mg/kg) decreases serum levels of glucose, insulin, and triglycerides in diabetic db/db mice.4 It reduces serum malondialdehyde (MDA) levels and stomach myeloperoxidase (MPO) activity in a mouse model of ethanol-induced gastric ulcers.5
1.Xu, M., Dong, P., Tian, X., et al.Drug interaction study of natural steroids from herbs specifically toward human UDP-glucuronosyltransferase (UGT) 1A4 and their quantitative structure activity relationship (QSAR) analysis for predictionPharmacol. Res.110139-150(2016) 2.Liu, M.-J., Wang, Z., Ju, Y., et al.The mitotic-arresting and apoptosis-inducing effects of diosgenyl saponins on human leukemia cell linesBiol. Pharm. Bull.27(7)1059-1065(2004) 3.Chen, X.-B., Wang, Z.-L., Yang, Q.-Y., et al.Diosgenin glucoside protects against spinal cord injury by regulating autophagy and alleviating apoptosisInt. J. Mol. Sci.19(8)2274(2018) 4.Wu, Y., Ye, F., Lu, Y., et al.Diosgenin glucoside protects against myocardial injury in diabetic mice by inhibiting RIP140 signalingAm. J. Transl. Res.10(11)3742-3749(2018) 5.Chen, T., Jiang, W., Zhang, H., et al.Protective effect of trillin against ethanol-induced acute gastric lesions in an animal modelRSC Adv.620081-20088(2016)
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