A triterpene with anticancer and senescence modifying activities
Epifriedelanol is a triterpene that has been found in U. davidiana root bark and has anticancer and senescence modifying activities.1 It increases levels of P-glycoprotein (P-gp) and multidrug resistance protein 2 (MDR2) and enhances doxorubicin-induced cytotoxicity in doxorubicin-resistant K562/ADM cells when used at concentrations ranging from 5 to 20 ?M. It also inhibits doxorubicin-induced senescence in isolated human dermal fibroblasts (HDFs), as well as replicative senescence in HDFs and human umbilical vein endothelial cells (HUVECs).2
1.Li, Y., Liao, Z., Wei, X., et al.Epifriedelanol enhances adriamycin-induced cytotoxicity towards K562/ADM cells by down regulating of P-gp and MRP2Xenobiotica1-28(2022) 2.Yang, H.H., Son, J.-K., Jung, B., et al.Epifriedelanol from the root bark of Ulmus davidiana inhibits cellular senescence in human primary cellsPlanta Med.77(5)441-449(2011)
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