A terpene trilactone with diverse biological activities
Ginkgolide J is a terpene trilactone originally isolated from G. biloba that has diverse biological activities. 1,2,3 It inhibits platelet aggregation induced by platelet-activating factor (PAF) in rabbit and human platelet-rich plasma (IC50s = 27 and 43.5 μg/ml, respectively).2 Ginkgolide J (1 μM) inhibits cell death induced by amyloid-β (1-42) in primary rat hippocampal neurons and reverses Aβ42-induced impairment of long-term potentiation (LTP) in the mouse CA1 region.3
1.Braquet, P., Esanu, A., Buisine, E., et al.Recent progress in ginkgolide researchMed. Res. Rev.11(3)295-355(1991) 2.Koch, E.Inhibition of platelet activating factor (PAF)-induced aggregation of human thrombocytes by ginkgolides: Considerations on possible bleeding complications after oral intake of Ginkgo biloba extractsPhytomedicine12(1-2)10-16(2005) 3.Vitolo, O., Gong, B., Cao, Z., et al.Protection against β-amyloid induced abnormal synaptic function and cell death by Ginkgolide JNeurobiol. Aging30(2)257-265(2009)
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