A coumarin with diverse biological activities
Scoparone is a coumarin that has been found in A. capillaris and has diverse biological activities.1,2,3,4,5 It inhibits angiotensin II-induced extracellular matrix (ECM) remodeling and cell proliferation and reduces levels of collagen I and fibronectin in isolated primary neonatal rat cardiac fibroblasts when used at concentrations ranging from 1 to 10 ?M.1 Scoparone suppresses PDGF-BB-induced rat aortic smooth muscle cell (RASMC) migration and wound healing in a scratch assay.2 In vivo, scoparone (3.5 mg/kg) reduces vascular neointima formation in a rat model of carotid artery balloon injury. Scoparone (80 mg/kg) reduces hepatocyte apoptosis, liver fibrosis, serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), and hepatic triglyceride levels in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine- and choline-deficient (MCD) diet.3 It reduces ulcer lesion area in a rat model of HCl- and ethanol-induced gastric ulcers.4 Scoparone also inhibits passive cutaneous anaphylaxis in rats.5
1.Fu, B., Su, Y., Ma, X., et al.Scoparone attenuates angiotensin II-induced extracellular matrix remodeling in cardiac fibroblastsJ. Pharmacol. Sci.137(2)110-115(2018) 2.Jung, S.H., Lee, G.B., Ryu, Y., et al.Inhibitory effects of scoparone from chestnut inner shell on platelet-derived growth factor-BB-induced vascular smooth muscle cell migration and vascular neointima hyperplasiaJ. Sci. Food Agric.99(9)4397-4406(2019) 3.Liu, B., Deng, X., Jiang, Q., et al.Scoparone alleviates inflammation, apoptosis and fibrosis of non-alcoholic steatohepatitis by suppressing the TLR4/NF-κB signaling pathway in miceInt. Immunopharmacol.75105797(2019) 4.Son, D.J., Lee, G.R., Oh, S., et al.Gastroprotective efficacy and safety evaluation of scoparone derivatives on experimentally induced gastric lesions in rodentsNutrients7(3)1945-1964(2015) 5.Choi, Y.H., and Yan, G.H.Anti-allergic effects of scoparone on mast cell-mediated allergy modelPhytomedicine16(12)1089-1094(2009)
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