Gap 27

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5mg

￥1456.00

1310.00

- +
10mg

￥2367.00

2130.00

- +
25mg

￥3246.00

2921.00

- +

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Selective gap junction blocker

货号：ajcp4480
CAS：198284-64-9
分子式：C60H101N15O17
分子量：1304.55
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Gap 27 is a peptide(Ser-Arg-Pro-Thr-Glu-Lys-Thr-Ile-Phe-Ile-Ile) derived from connexin 43 that is a selective gap junction blocker.

Connexins, or gap junctions, are a family of structurally-related transmembrane proteins. Gap junctions contain channels that allow the passage of ions and small molecules between adjacent cells. This intercellular communication has been implicated in the coordination of cellular responses to intracellular signaling molecules. Calcium and inositol phosphates are among the second messengers that can pass through gap junction channels. This synthetic connexin-mimetic peptide, Gap 27, was used to evaluate the contribution of gap-junctional communication to osteoclastic bone resorption. It was concluded that gap-junctional communication is necessary for proper bone remodeling.

Reference：
1. Berthoud, V. et al. Am. J. Physiol. Lung Cell Mol. Physiol. 279, 619 (2000)
2. Ilvesaro, J. et al. BMC Musculoskel. Disord. 2, 10 (2001)
3. Chaytor, A. et al. Brit. J. Pharmacol. 144, 108 (2005)
4. Boitano, S. and H. Evans Am. J. Physio.l Lung Cell Mol. Physiol. 279, L623 ( 2000).