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- HDAC (Histone deacetylases)
- BRD-6929
BRD-6929
An HDAC1 and HDAC2 inhibitor
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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1mg￥1238.001238.00- +
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5mg￥3500.003500.00- +
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- 货号: ajcz1115
- CAS: 849234-64-6
- 别名: JQ12
- 分子式: C19H17N3O2S
- 分子量: 351.42
- 纯度: ＞98%
- 溶解度: DMSO: 5 mg/mL (14.23 mM)
- 储存: Store at -20°C
- 库存: 现货
Background
BRD6929 is a histone deacetylase 1 (HDAC1) and HDAC2 inhibitor (IC50s = 0.04 and 0.1 ?M, respectively, for the recombinant human enzymes).1 It is selective for HDAC1 and HDAC2 over HDAC3 and HDAC8 (IC50s = >20 ?M for both). BRD6929 inhibits proliferation of HCT116 human colon cancer cells but not non-cancerous human mammary epithelial cells (HMECs; IC50s = 4 and >50 ?M, respectively).
1.Moradei, O.M., Mallais, T.C., Frechette, S., et al.Novel aminophenyl benzamide-type histone deacetylase inhibitors with enhanced potency and selectivityJ. Med. Chem.50(23)5543-5546(2007)
