瑞德西韦 Remdesivir(GS-5734)
瑞德西韦，英文名字：Remdesivir，别名：GS-5734，CAS：1809249-37-3是一种核苷类似物，具有一定的抗冠状病毒（Coronaviruses）活性，在 HAE 细胞中，对 SARS-CoV 和 MERS-CoV 的 EC50 值为 74 nM，在延迟脑肿瘤细胞中，对鼠肝炎病毒的 EC50 值为 30 nM。Remdesivir 有潜力用于 2019-nCoV (COVID-19) 研究。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
-
包装价格促销价数量
-
5mg￥0.00940.00- +
-
25mg￥0.001875.00- +
-
100mg￥0.002250.00- +
-
500mg￥0.003750.00- +
- 货号: ajcz107
- CAS: 1809249-37-3
- 别名: 瑞德西韦;GS-5734;伦地西韦;瑞德西韦;伦德西韦;瑞德沙韦
- 分子式: C27H35N6O8P
- 分子量: 602.58
- 纯度: ＞99%
- 溶解度: DMSO : 100 mg/mL (165.95 mM; Need ultrasonic)
- 储存: Store at -20°C
- 库存: 现货
Background
Remdesivir is a nucleoside analogue, with effective antiviral activity, with EC50s of 74 nM for ARS-CoV and MERS-CoV in HAE cells, and 30 nM for murine hepatitis virus in delayed brain tumor cells.
Remdesivir (GS-5734) is a potent antiviral agent. Remdesivir inhibits murine hepatitis virus (MHV) with an EC50 of 30 nM, and blocks SARS-CoV and MERS-CoV in HAE cells with EC50s of both 74 nM in HAE cells after treatment for 24 h[1].
References
[1]. Agostini ML, et al. Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease. MBio. 2018 Mar 6;9(2). pii: e00221-18.
