Hydroxychloroquine
Hydroxychloroquine Sulfate (NSC 4375, HCQ) is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9.
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包装价格促销价数量
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250mg￥75.0060.00- +
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1g￥125.00100.00- +
- 货号: ajci76422
- CAS: 118-42-3
- 别名: 羟氯喹；羟基氯喹
- 分子式: C18H26ClN3O
- 分子量: 335.87
- 纯度: ＞98%
- 溶解度: DMSO : ≥ 100 mg/mL (297.73 mM); 1M HCl : 100 mg/mL (297.73 mM; adjust pH to 2 with HCl); H2O : 1.67 mg/mL (4.97 mM; ultrasonic and warming and heat to 60°C)
- 储存: Store at -20°C
- 库存: 现货
Background
Hydroxychloroquine Sulfate (NSC 4375, HCQ) is an antimalarial agent used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune, inflammatory and dermatologic conditions. Also acts as an inhibitor of autophagy and toll-like receptor (TLR) 7/9.
Hydroxychloroquine Sulfate is a potent inhibitor of autophagy. It prevents lysosomal acidification, thereby interfering with a key step in the autophagic process.HCQ treatment inhibits RCC (renal cell cancer) cell growth, promotes apoptosis, inhibits mitochondrial oxygen consumption, and increases rates of glycolysis[2].
The treatment of Hydroxychloroquine Sulfate reduces the infarct size in an in vivo rat model of I/R injury and the cardioprotective effect of Hydroxychloroquine is ERK1/2 dependent[3]. In addition, Hydroxychloroquine Sulfate shows an early vascular protective effect. HCQ seems to prevent the occurrence of endothelial dysfunction(ED) in treated animals[4].
[1] Ramser B, et al.J Invest Dermatol, 2009,129(10):2419-26. [2] Lee HO, et al. PLoS One. 2015, 10(7): e0131464. [3] Bourke L, et al. PLoS One. 2015, 10(12):e0143771.
