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Mnm5s2U 存在于赖氨酸和谷氨酸 tRNA 反密码子中,具有在 tRNA 中摆动修饰功能。
货号:ajcs1005
CAS:32860-54-1
分子式:C11H17N3O5S
分子量:303.33
纯度:>98%
存储:Store at -20°C
库存:现货
Background:
Mnm5s2U, found in lysine and glutamate tRNA anticodon, has an wobble modification function in tRNA[1].
In Vitro,an E. coli strain deficient in 5-methylaminomethyl-2-thiouridine (mnm5s2U) (found in lysine and glutamate tRNA anticodon) is more vulnerable to oxidative RNA damage compared to its wildtype strain suggesting an auxiliary function for the mnm5s2U modification.[1].
参考文献:
[1]. Mariana Estevez, et al. Oxidative Damage to RNA is Altered by the Presence of Interacting Proteins or Modified Nucleosides. Front Mol Biosci. 2021 Jul 1;8:697149.
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