Mnm5s2U（5-methylaminomethyl-2-thiouridine）

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5mg

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Mnm5s2U 存在于赖氨酸和谷氨酸 tRNA 反密码子中，具有在 tRNA 中摆动修饰功能。

货号：ajcs1005
CAS：32860-54-1
分子式：C11H17N3O5S
分子量：303.33
纯度：＞98%
存储：Store at -20°C

库存：现货

Background:

Mnm5s2U, found in lysine and glutamate tRNA anticodon, has an wobble modification function in tRNA[1].

In Vitro,an E. coli strain deficient in 5-methylaminomethyl-2-thiouridine (mnm5s2U) (found in lysine and glutamate tRNA anticodon) is more vulnerable to oxidative RNA damage compared to its wildtype strain suggesting an auxiliary function for the mnm5s2U modification.[1].

参考文献：

[1]. Mariana Estevez, et al. Oxidative Damage to RNA is Altered by the Presence of Interacting Proteins or Modified Nucleosides. Front Mol Biosci. 2021 Jul 1;8:697149.