Mnm5s2U
Mnm5s2U 存在于赖氨酸和谷氨酸 tRNA 反密码子中，具有在 tRNA 中摆动修饰功能。
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包装价格促销价数量
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5mg￥8125.006500.00- +
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10mg￥15000.0012000.00- +
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- 货号: ajcs1005
- CAS: 32860-54-1
- 别名: Mnm5s2U；5-methylaminomethyl-2-thiouridine；mnm-5s2U, mnm 5s2U
- 分子式: C11H17N3O5S
- 分子量: 303.33
- 纯度: ＞98%
- 溶解度: Soluble in DMSO
- 储存: Store at -20°C
- 库存: 现货
Background
Mnm5s2U, found in lysine and glutamate tRNA anticodon, has an wobble modification function in tRNA[1].
In Vitro,an E. coli strain deficient in 5-methylaminomethyl-2-thiouridine (mnm5s2U) (found in lysine and glutamate tRNA anticodon) is more vulnerable to oxidative RNA damage compared to its wildtype strain suggesting an auxiliary function for the mnm5s2U modification.[1].
参考文献：
[1]. Mariana Estevez, et al. Oxidative Damage to RNA is Altered by the Presence of Interacting Proteins or Modified Nucleosides. Front Mol Biosci. 2021 Jul 1;8:697149.
