A neuropeptide with diverse biological activities
Sterigmatocystin-13C18 is intended for use as an internal standard for the quantification of sterigmatocystin by GC- or LC-MS. Sterigmatocystin is a mycotoxin that has been found in Aspergillus.1,2 It is lethal to rats (LD50 = 60 mg/kg) and chick embryos (LD50s = 5-7 µg/embryo).2 Sterigmatocystin (100 and 1,000 ppb in drinking water) induces gastritis, as well as intestinal polyp formation and metaplasia in aged Mongolian gerbils.1 It induces formation of lung and liver adenomas and malignant lymphomas in newborn mice.3
1.Kusunoki, M., Misumi, J., Shimada, T., et al.Long-term administration of the fungus toxin, sterigmatocystin, induces intestinal metaplasia and increases the proliferative activity of PCNA, p53, and MDM2 in the gastric mucosa of aged Mongolian gerbilsEnviron. Health Prev. Med.16(4)224-231(2011) 2.Schroeder, H.W., and Kelton, W.H.Production of sterigmatocystin by some species of the genus Aspergillus and its toxicity to chicken embryos.Appl. Microbiol.30(4)589-591(1975) 3.Fujii, K., Kurata, H., Odashima, S., et al.Tumor induction by a single subcutaneous injection of sterigmatocystin in newborn miceCancer Res.36(5)1615-1618(1976)
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