ENPP3 Inhibitor
An ENPP3 inhibitor
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包装价格促销价数量
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1mg￥1275.001020.00- +
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5mg￥6050.004840.00- +
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10mg￥11475.009180.00- +
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- 货号: ajcf12358
- CAS: 333413-02-8
- 别名:
- 分子式: C21H19N5O4S2
- 分子量: 469.5
- 纯度: ＞98%
- 溶解度: DMF: insol,DMSO: 2 mg/ml,Ethanol: insol,PBS (pH 7.2): insol
- 储存: -20°C
- 库存: 现货
Background
ENPP3 inhibitor is an inhibitor of ectonucleotide pyrophosphatase/phosphodiesterase family member 3 (ENPP3; Ki = 53.7 nM).1 It is selective for ENPP3 over ENPP1, ENPP2, tissue-nonspecific alkaline phosphatase (TNAP), ecto-5′-nucleotidase (CD73), nucleoside triphosphate diphosphohydrolase 1 (NTPDase 1), NTPDase 2, and NTPDase 3. ENPP3 inhibitor also inhibits carbonic anhydrase II (CAII) and CAIX (Kis = 74.7 and 20.3 nM, respectively).
1.Lee, S.-Y., Namasivayam, V., Boshta, N.M., et al.Discovery of potent nucleotide pyrophosphatase/phosphodiesterase3 (NPP3) inhibitors with ancillary carbonic anhydrase inhibition for cancer (immuno)therapyRSC Med. Chem.12(7)1187-1206(2021)
