TRAP-6 amide (trifluoroacetate salt)
A peptide PAR1 agonist
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包装价格促销价数量
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5mg￥1275.001020.00- +
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10mg￥2312.001850.00- +
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50mg￥8925.007140.00- +
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100mg￥15137.0012110.00- +
- 货号: ajcf12672
- CAS:
- 别名: Ser-Phe-Leu-Leu-Arg-Asn-NH2, SFLLRN-NH2, Thrombin Receptor Agonist Peptide-6 amide
- 分子式: C34H57N11O8 ? XCF3COOH
- 分子量: 747.9
- 纯度: ＞98%
- 溶解度: DMSO: 12 mg/mL,Ethanol: Slightly soluble,PBS (pH 7.2): 5 mg/mL
- 储存: -20°C
- 库存: 现货
Background
TRAP-6 amide is a peptide agonist of proteinase-activated receptor 1 (PAR1).1 It induces platelet aggregation in vitro (EC50 = 0.15 µM). TRAP-6 amide (30 µM) induces relaxation of isolated guinea pig internal anal sphincter strips.2 It also increases cigarette smoke extract-induced IL-8 release from isolated human bronchial epithelial cells when used at a concentration of 50 µM.3
1.Elliott, J.T., Hoekstra, W.J., Derian, C.K., et al.Tritiated photoactivatable analogs of the native human thrombin receptor (PAR-1) agonist peptide, SFLLRN-NH2J. Pept. Res.57(6)494-506(2001) 2.Huang, S.-C.Proteinase-activated receptor-1 (PAR1) and PAR2 mediate relaxation of guinea pig internal anal sphincterRegul. Pept.18946-50(2014) 3.Montalbano, A.M., Chiappara, G., Albano, G.D., et al.Expressioctivation of PAR-1 in airway epithelial cells of COPD patients: Ex vivo/in vitro studyInt. J. Mol. Sci.22(19)10703(2021)
