LDC4297 hydrochloride
A CDK7 inhibitor
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包装价格促销价数量
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5mg￥925.00740.00- +
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10mg￥1562.001250.00- +
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25mg￥3262.002610.00- +
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50mg￥5400.004320.00- +
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100mg￥9175.007340.00- +
- 货号: ajcf14620
- CAS: 2319747-14-1
- 别名:
- 分子式: C23H29ClN8O
- 分子量: 468.98
- 纯度: ＞98%
- 溶解度:
- 储存: 4°C, away from moisture and light
- 库存: 现货
Background
LDC-4297 is an inhibitor of cyclin-dependent kinase 7 (CDK7; IC50 = <5 nM).1 It is selective for CDK7 over CDK4, CDK6, and CDK9 (IC50s = >10, >10, and 1.71 μM), however, it also inhibits CDK2 and CDK1 (IC50s = 6.4 and 53.7 nM, respectively). LDC-4297 (10-100 nM) induces apoptosis in A549, HeLa, and HCT116 cancer cells in a concentration-dependent manner. It inhibits human cytomegalovirus (HCMV) replication in human fibroblasts (EC50 = 24.5 nM).2 LDC-4297 also reduces replication of Herpesviridae, Adenoviridae, Poxviridae, Retroviridae, and Orthomyxoviridae family viruses (EC50s = 0.02-1.13 μM).
1.Kelso, T.W.R., Baumgart, K., Eickhoff, J., et al.Cyclin-dependent kinase 7 controls mRNA synthesis by affecting stability of preinitiation complexes, leading to altered gene expression, cell cycle progression, and survival of tumor cellsMol. Cell. Biol.34(19)3675-3688(2014) 2.Hutterer, C., Eickhoff, J., Milbradt, J., et al.A novel CDK7 inhibitor of the pyrazolotriazine class exerts broad-spectrum antiviral activity at nanomolar concentrationsAntimicrob. Agents Chemother.59(4)2062-2071(2015)
