DDR1-IN-6
DDR1-IN-6 是选择性的盘状结构域受体家族成员 1 (DDR1) 抑制剂，IC50 为 9.72 nM。DDR1-IN-6 抑制 DDR1b (Y513) 自磷酸化，IC50 为 9.7 nM。DDR1-IN-6 具有抗癌活性。
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包装价格促销价数量
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5mg￥1962.001570.00- +
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10mg￥3425.002740.00- +
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25mg￥6800.005440.00- +
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50mg￥10687.008550.00- +
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100mg￥15862.0012690.00- +
- 货号: ajcf14680
- CAS: 2416021-47-9
- 别名:
- 分子式: C23H14F3N5O
- 分子量: 433.39
- 纯度: ＞98%
- 溶解度:
- 储存: 4°C, away from moisture and light
- 库存: 现货
Background
DDR1-IN-6 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC50 of 9.72 nM. DDR1-IN-6 inhibits auto-phosphorylation DDR1b (Y513) with an IC50 of 9.7 nM. DDR1-IN-6 has anti-cancer activity[1].
DDR1-IN-6 (compound 1; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC50=13 nM)[1].
DDR1-IN-6 (72 hours) has cytotoxicity in LX-2 cells (CC50=3 μM)[1].
DDR1-IN-6 (0-30 μM) has anti-proliferation effects on primary tumor cells freshly isolated from PC-07-0024 (IC50=5.7 μM of 3 days; IC50=2.65 μM of 6 days) and LU-01-0523 derived xenograft (PDX) tumor model (IC50>30 μM of 3 days; IC50>30 μM of 6 days)[1].
