T01-1
T01-1 是一种抗癌剂 (喜树碱衍生物)，具有较好的抗肿瘤细胞增殖活性。
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包装价格促销价数量
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100mg￥14100.0011280.00- +
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- 货号: ajcf17316
- CAS: 2356229-14-4
- 别名:
- 分子式: C26H29N3O6S
- 分子量: 511.59
- 纯度: ＞98%
- 溶解度:
- 储存: Store at -20°C, protect from light
- 库存: 现货
Background
T01-1 is an anticancer agent (camptothecin derivative) with good anti-proliferative activity[1].
T01-1 (0-50 nM; 3 days) anti-proliferative activity in HCC1806 cells[1].
Cell Proliferation Assay[1]
| Cell Line: | HCC1806 cells |
| Concentration: | 0-50 nM |
| Incubation Time: | 3 days |
| Result: | Inhibited cell proliferation with an EC50 value of 6.7 nM. |
T01-1 (1 mg/kg; i.v.; single) shows T1/2 values of 2.78 and 1.97 h in female and male rats, respectively[1].
| Animal Model: | Sprague Dawley rat (half male and half female)[1]. | |||||||||||||||||||||
| Dosage: | 1 mg/kg | |||||||||||||||||||||
| Administration: | Intravenous injection; single | |||||||||||||||||||||
| Result: |
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[1]. Li Deliang, et al. Camptothecin derivative and water-soluble prodrug, pharmaceutical composition preparation method, and application. Patent WO2020156189A1.
