Deruxtecan analog 2 (example 9 P3) 是一种 Deruxtecan 类似物。Deruxtecan analog 2 是一种药物-linker 偶联物,由 Camptothecin 和 linker 组成。Camptothecin (CPT) 是一种 Topo I 抑制剂,对结直肠癌、乳腺癌、肺癌和卵巢癌具有抗肿瘤活性。Deruxtecan analog 2 可用于制备抗-EGFR2 的 ADC 药物。
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Deruxtecan analog 2 (example 9 P3) is a Deruxtecan analog. Deruxtecan analog 2 is a drug-linker conjugate composed of Camptothecin and a linker. Camptothecin (CPT) is a Topo I inhibitor with antineoplastic activity against colorectal, breast, lung and ovarian cancers. Deruxtecan analog 2 can be used for the preparation anti-FGFR2 ADC[1].
[1]. Daly Christopher, et, al. Anti-FGFR2 antibodies and antibody-drug conjugates methods of use thereof. Patent WO2022087243.