LP-184
LP-184 (compound 6)，一种酰基氟乙烯类似物，能够抑制肿瘤生长。LP-184 在卵巢、结肠、前列腺和胰腺细胞系中具有有效的抗癌活性，来自专利 WO2007019308A2。
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包装价格促销价数量
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5mg￥58775.0047020.00- +
- 货号: ajcf20490
- CAS: 924835-67-6
- 别名:
- 分子式: C16H20N2O4
- 分子量: 304.34
- 纯度: ＞98%
- 溶解度: DMSO : 100 mg/mL (328.58 mM; Need ultrasonic)
- 储存: Store at -20°C
- 库存: 现货
Background
IC50: 0.68 μM (HT29); 0.6 μM (OVCAR-3); 16 μM (AsPC-1); 0.14 μM (PC-3)
LP-184 (compound 6), an acylfulvene analog, inhibits tumor growth. LP-184 has potent anti-cancer activity in the ovarian, colon, prostate and pancreatic cell lines. (patent WO2007019308A2).
LP-184 inhibits the growth of HT29, OVCAR-3, AsPC-1 and PC-3, with GI50s of 0.68, 0.6, 16 and 0.14 μM, respectively[1].
LP-184 displays IC50s of 800nM and 210 nM for anti-cancer activitie in the tmidine incorporation into cellular DNA (2 hour) and Trypan blue (48 hour) assay[1].
LP-184 (7.5 and 10 mg/kg; i.p.; 21 day) has potent 15 anti-tumor activity against MV522 tumors, producing 4/6 and 5/5 partial responses, respectively[1].
| Animal Model: | Mice (MV522 tumors) [1] |
| Dosage: | 7.5 and 10 mg/kg |
| Administration: | I.p; 21day |
| Result: | Effective agent for human anti-tumor therapy. |
[1]. Trevor C. Mcmorris, et al. Illudin analogs useful as anticancer agents. WO2007019308A2.
