Pan KRas-IN-1
Pan KRas-IN-1 是一种泛 KRas 抑制剂，能够用于对 KRas G12C 抑制剂产生的癌症耐药性的研究。
此产品仅用于科学研究，我们不为任何个人用途提供产品和服务
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包装价格促销价数量
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5mg￥8850.007080.00- +
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10mg￥14100.0011280.00- +
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- 货号: ajcf20996
- CAS: 2791263-84-6
- 别名:
- 分子式: C33H36F3N5O3
- 分子量: 607.67
- 纯度: ＞98%
- 溶解度: DMSO : 100 mg/mL (164.56 mM; Need ultrasonic)
- 储存: 4°C, away from moisture and light
- 库存: 现货
Background
Pan KRas-IN-1 is a pan KRas inhibitor, can be used for agent resistance in Adagrasib in mouse 3T3 fibroblasts, with IC50s of 32 nM (G12A), 28.1 nM (G12C), 20.25 nM (G12D), 1742 nM (G12R), 94 nM (G12V), 50 nM (G12W), 610 nM (G13D), 58 nM (Q61H)[1].
[1]. Wang Xiaolun, et al. Preparation of azaquinazoline pan-KRas inhibitors: World Intellectual Property Organization, WO2022132200[P]. 2022-06-23.
