SKF 83822 是一种非典型的多巴胺 D1 受体激动剂。SKF 83822 激活腺苷酸环化酶 (AC)，但不激活磷脂酶C (PLC)。SKF 83822 也被证明可以通过 cAMP 的产生来刺激 AC。SKF 83822 可用于精神分裂症的研究。
SKF 83822 is an atypical agonist of dopamine D1 receptor. SKF 83822 activates adenylyl cyclase (AC), but not Produced a strong rotational response at 50 μg/kg which was approximately midway between that produced by the 25 and 100 μg/kg doses in the first experiment.
Could be inhibited by antagonist of dopamine D1 receptor, SCH 23390.
[1]. Wirtshafter D. Rotation and immediate-early gene expression in rats treated with the atypical D1 dopamine agonist SKF 83822. Pharmacol Biochem Behav. 2007 Mar;86(3):505-10.
[2]. Peacock L, et al. Aberrant behavioral effects of a dopamine D1 receptor antagonist and agonist in monkeys: evidence of uncharted dopamine D1 receptor actions. Biol Psychiatry. 2001 Oct 1;50(7):501-9.
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