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SLU-PP-915 是一种 ERR 激动剂。SLU-PP-915 对 ERRα、ERRβ 和 ERRγ 的 EC50 值约为 400 nM。SLU-PP-915 在维持氧化代谢、心力衰竭中有潜在的应用。
SLU-PP-915 is an agonist of ERR. SLU-PP-915 has an EC50 value of approximately 400 nM for 0.71
[1]. Xu W, et al. The Cardiac Protective Effects of Novel Synthetic Pan-Estrogen Related Receptor Agonists Slu-pp-332 and Slu-pp-915[J]. Circulation, 2021, 144(Suppl_1): A9682-A9682.
[2]. Xu W, et al. Novel ERR pan-agonists ameliorate heart failure through boosting cardiac fatty acid metabolism and mitochondrial function[J]. bioRxiv, 2022: 2022.02. 14.480431.
[3]. Losby M K, et al. The Estrogen Receptor-Related Orphan Receptors (ERRs) Regulate Autophagy through TFEB[J]. bioRxiv, 2023: 2023.03. 02.530836.
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