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Trecovirsen (GEM91) 是一种靶向 HIV gag 基因的反义寡核苷酸。
Trecovirsen (GEM91) is a 25-mer antisense phosphorothioate oligonucleotide targeted at the gag site of the HIV gene.
[1]. Séréni D, Tubiana R, Lascoux C, et al. Pharmacokinetics and tolerability of intravenous trecovirsen (GEM 91), an antisense phosphorothioate oligonucleotide, in HIV-positive subjects. J Clin Pharmacol. 1999;39(1):47-54.
[2]. Pedziwiatr-Werbicka E, Fuentes E, Dzmitruk V, et al. Novel 'Si-C' carbosilane dendrimers as carriers for anti-HIV nucleic acids: studies on complexation and interaction with blood cells. Colloids Surf B Biointerfaces. 2013;109:183-189.
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