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Tregalizumab 是一种 人源化抗人 CD4 单克隆抗体 (IgG1 型),能在体外选择性地激活调节性 T 细胞 (Tregs) 的抑制特性。Tregalizumab 可用于自身免疫性疾病 (Treg 活性不足导致) 以及过敏的研究。
Tregalizumab is a humanized anti-human Induced CD4 down-modulation of T cells.
[1]. K?nig M, et al. Tregalizumab - A Monoclonal Antibody to Target Regulatory T Cells. Front Immunol. 2016 Jan 25;7:11.
[2]. Vogel S, et al. Antibody induced CD4 down-modulation of T cells is site-specifically mediated by CD64(+) cells. Sci Rep. 2015 Dec 16;5:18308.
[3]. Helling B, et al. A specific CD4 epitope bound by tregalizumab mediates activation of regulatory T cells by a unique signaling pathway. Immunol Cell Biol. 2015 Apr;93(4):396-405.
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