STING Agonist 12L

STING激动剂

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库存: 现货

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数量
1mg

￥1475.00

1180.00

- +
5mg

￥6975.00

5580.00

- +
10mg

￥13087.00

10470.00

- +

已选 0 种 0 瓶

金额: ￥0.00

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货号: ajcf22876
CAS: 2913152-30-2
别名: Stimulator of Interferon Genes Agonist 12L
分子式: C18H10FN5O3
分子量: 363.3
纯度: ＞98%
溶解度: DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 5 mg/ml,PBS (pH 7.2): 2 mg/ml
储存: Store at -20°C
库存: 现货

Background

STING agonist 12L is an agonist of stimulator of interferon genes (STING).¹ It binds to wild-type STING (IC₅₀ = 1.15 μM), as well as the STING R232, AQ, and Q variants (IC₅₀s = 1.06, 0.61, and 1.12 μM, respectively) and induces reporter gene expression in THP-1 and RAW 264.7 cells (EC₅₀s = 0.38 and 12.94 μM, respectively). STING agonist 12L (5 μM) induces IFNB1, CXCL10, and IL6 mRNA expression in THP-1 cells. In vivo, STING agonist 12L (10 mg/kg) increases plasma IFN-β levels and reduces tumor volume and the number of lung metastases in a B16/F10 murine melanoma model.

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STING Agonist 12L

STING Agonist 12L详情

Background

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