ZLY28

一种FXR激动剂和FABP1抑制剂。

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库存: 现货

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数量
1mg

￥2412.00

1930.00

- +
5mg

￥10150.00

8120.00

- +

已选 0 种 0 瓶

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货号: ajcf23356
CAS:
别名:
分子式: C29H23Cl2NO4
分子量: 520.4
纯度: ＞98%
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml
储存: Store at -20°C
库存: 现货

Background

ZLY28 is a farnesoid X receptor (FXR) agonist and an inhibitor of fatty acid binding protein 1 (FABP1).¹ It selectively induces reporter gene expression in HepG2 cells expressing human FXR (EC₅₀ = 143 nM) over cells expressing 19 other receptors (EC₅₀s = >10,000 nM for all). ZLY28 selectively inhibits FABP1 (IC₅₀ = 2.7 μM) over FABP3 (IC₅₀ = >30 μM) but also inhibits FABP4 (IC₅₀ = 6.3 μM). In vivo, ZLY28 (20 mg/kg) induces FXR-related gene expression in the ileum but not the liver in a mouse model of carbon tetrachloride-induced non-alcoholic steatohepatitis (NASH). It also reduces hepatocyte ballooning, as well as hepatic lobular inflammation and steatosis in the same model.

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生命科学

有机化学

无机化学

材料科学

ZLY28

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Background

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