Background
13C28-Bongkrekic Acid is intended for use as an internal standard for the quantification of bongkrekic acid by GC- or LC-MS. Bongkrekic acid is polyketide and bacterial toxin that has been found in B. gladioli.1,2 It is an inhibitor of ADP/ATP translocase (AAT), a carrier protein that imports ADP into the mitochondrial matrix and exports ATP into the intermembrane space.1,3 It prevents ADP import and inhibits mitochondrial respiration (Ki = 20 nM in isolated rat liver mitochondria).4,5 Bongkrekic acid induces cell death in MCF-7 human breast cancer cells deprived of estradiol for six months (EC50 = 2.58 μM).6 It is toxic to mice (LD50s = 0.68-6.84 mg/kg, p.o.).7
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