NCI 126224

一种TLR4拮抗剂

原价

￥612-7562

价格

￥ 490-6050

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库存: 现货

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产品引用

货号: ajcf23586
CAS: 65974-52-9
别名: NSC 126224
分子式: C12H11NO6
分子量: 265.2
纯度: >98%
溶解度: Chloroform: Soluble,Methanol: Soluble
储存: Store at -20°C
库存: 现货

Background

NCI 126224 is a toll-like receptor 4 (TLR4) antagonist.¹ NCI 126224 selectively inhibits nitric oxide (NO) production induced by the TLR4 agonist LPS (IC₅₀ = 0.31 μM) over the TLR7/8 agonist R-848 , TLR1/2 agonist Pam₃CSK₄ , and TLR3 agonist poly(I:C) in RAW 264.7 macrophages but also inhibits NO production induced by the TLR2/6 agonist FSL-1 in the same cells at 0.6 μM. NCI 126224 inhibits LPS-induced NF-κB activity in a reporter assay using BV-2 microglial cells and LPS-induced increases in IL-1β and TNF-α levels in RAW 264.7 macrophages (IC₅₀s = 5.92, 0.42, and 1.54 μM, respectively).

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生命科学

有机化学

无机化学

材料科学

NCI 126224

NCI 126224详情

Background