Background
Malathion-d10 is intended for use as an internal standard for the quantification of malathion by GC- or LC-MS. Malathion is an organophosphate insecticide that inhibits acetylcholinesterase (AChE; IC50s = 370 and 160 μM for free and immobilized AChE, respectively, from bovine erythrocytes).1 It is ovicidal and adulticidal to laboratory colonies of body lice when used at concentrations of 0.001 and 0.05%, respectively.2 It is toxic to rats (LD50 = 750 mg/kg) and teratogenic to zebrafish when used at concentrations ranging from 2 to 3 mg/L.3,4 Formulations containing malathion have been used in the treatment of lice.
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