Background
Bifenthrin-d5 is intended for use as an internal standard for the quantification of bifenthrin by GC- or LC-MS. Bifenthrin is a synthetic pyrethroid insecticide and a slow activator of voltage-gated sodium channel 1.8 (Nav1.8).1 It is toxic to A. gambiae and C. quinquefasciatus mosquitos (LD50s = 0.15 and 0.16 ng/mg, respectively) and reduces the number of insidious flower bugs (O. insidiosus) in corn when applied at a concentration of 168 g/ha.2,3 Bifenthrin is toxic to D. magna (LC50 = 12.4 μg/L) and inhibits D. magna reproduction when used at a concentration of 1 μg/L.4 It induces fine- and whole-body tremors and decreases motor activity in rats when administered at a dose of 20 mg/kg.5 Bifenthrin (8 mg/kg) decreases body mass and locomotor activity, increases memory deficits in the passive avoidance test, as well as decreases the concentration of blood erythrocytes, increases lymphocyte hepatic infiltration, and increases the activity of hepatic alanine transaminase (ALT) in mice.6 Formulations containing bifenthrin have been used as insecticides in residential and agricultural settings.
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