Background
Cyfluthrin-d6 is intended for use as an internal standard for the quantification of cyfluthrin by GC- or LC-MS. Cyfluthrin is a pyrethroid insecticide and a modulator of voltage-gated sodium channels (Nav).1,2 It slowly activates rat recombinant Nav1.8 channels, delays inactivation by longer than 40 ms, and induces persistent tail currents in channels expressed in X. laevis oocytes.1 It also decreases the mean burst rate in rat primary neurons (IC50 = 0.99 μM, respectively).2 Cyfluthrin is toxic to various insects, including A. melinus, G. ashmeadi, E. eremicus, and E. formosa (LC50s = 7, 67, 96, and 63 ng/ml, respectively) and the A. sinensis mosquito (LC50 = 0.446 ppm).3,4 It is also toxic to A. mellifera honeybees (LD50 = 0.22 ppm), affecting locomotor activity and wing fanning behavior with an increase in the mean bout duration of time spent upside down, indicating disruption of the righting reflex, and a decrease in wing fanning behavior when administered at a dose of 10 ng/bee.5 Formulations containing cyfluthrin have been used for the control of insects in agriculture and for non-commercial purposes.
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