Background
(±)-Linalool-d3 is intended for use as an internal standard for the quantification of (±)-linalool by GC- or LC-MS. (±)-Linalool is a monoterpene alcohol that has been found in C. sativa, C. indica, and hemp with diverse biological activities.1,2,3,4,5,6 It induces cell cycle arrest at the G0/G1 and G2M phase in U937 and HeLa cells, respectively.2 (±)-Linalool is cytotoxic to U937 and HeLa cells (IC50s = 2.59 and 11.02 μM, respectively). It induces recruitment of a PGC-1α coactivator peptide to the PPARα ligand binding domain (EC50 = 5.45 μM in a TR-FRET assay).3 In vivo, (±)-linalool reduces plasma triglyceride concentration in mice fed a Western diet and transgenic mice expressing human ApoE2, but not PPARα-/- mice. It has molluscicidal and larvicidal effects in vitro (LC50s = 0.25 and 0.07 mg/L for O. hupensis and S. japonicium, respectively), and it reduces the amount of schistosomulum recovered from mouse skin after S. japonicium challenge infection.4 (±)-Linalool (10-40 mg/kg) reduces the number of macrophages and neutrophils, as well as the production of TNF-α, IL-6, IL-1β, IL-8, and MCP-1, in bronchoalveolar lavage fluid (BALF) in a mouse model of cigarette smoke-induced acute lung inflammation.5 It also decreases immobility time in the forced swim test in mice, indicating antidepressant-like activity.6
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