LDN-192960 hydrochloride

An inhibitor of haspin and DYRK2

价格

￥ 0-4060

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库存: 现货

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产品引用

货号: ajcf23796
CAS: 2309172-48-1
别名:
分子式: C18H22Cl2N2O2S
分子量: 401.35
纯度: >98%
溶解度: DMSO: 33 mg/ml,PBS (pH 7.2): 10 mg/ml
储存: Store at -20°C
库存: 现货

Background

LDN-192960 is an inhibitor of haspin protein kinase and dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 (DYRK2) with IC₅₀ values of 10 and 48 nM, respectively.¹ It is selective for haspin and DYRK2 over TRKB, CLK1, DYRK1A, DYRK3, ROS, HIPK1, HIPK2, PIM-1, and PIM-2 kinases (IC₅₀s = 720-91,000 nM).

1.Cuny, G.D., Robin, M., Ulyanova, N.P., et al.Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitorsBioorg. Med. Chem. Lett.20(12)3491-3493(2010)

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信号通路

生命科学

有机化学

无机化学

材料科学

LDN-192960 hydrochloride

LDN-192960 hydrochloride详情

Background