Poly(2-hydroxyethyl methacrylate) (MW 20000) 是生物材料领域最重要的水凝胶之一。Poly(2-hydroxyethyl methacrylate) 是隐形眼镜的基本成分，还用于软组织的植入，腕骨和骨的合成移植，神经系统组织的再生，药物的传递等。
Poly(2-hydroxyethyl methacrylate) (MW 20000) is one of the most important hydrogels in the biomaterials world. Poly(2-hydroxyethyl methacrylate) is the basic component of contact lenses, and is also used in implantation of soft tissues, synthetic transplant for gristle and bone, regeneration of neurotic tissue, transmission of drug and etc[1].
Poly(2-hydroxyethyl methacrylate) (PolyHEMA) retains moisture content similar to the live tissue and is resistant to degradation and absorption by the host cells. It can be easily manufactured in a variety of shapes and can be readily sterilized[1]. Proliferation rate of the cells that had been cultured on Poly(2-hydroxyethyl methacrylate) is reduced; Poly(2-hydroxyethyl methacrylate) does not induce cell death in the hRPE cultures. Human retinal pigment epithelium (RPE) cells cultured on Poly(2-hydroxyethyl methacrylate) formed many giant spheroid colonies. The giant colonies are re-cultured and the presence of retinal progenitor markers and markers of hRPE cells are detected in cell cultures on Poly(2-hydroxyethyl methacrylate)[1].
参考文献:
[1]. Fatemeh Nazemroaya, et al. Induced Retro-Differentiation of Human Retinal Pigment Epithelial Cells on PolyHEMA. J Cell Biochem. 2017 Oct;118(10):3080-3089.
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