Background
Guanosine 5′-triphosphate (GTP) acts as a substrate for the synthesis of RNA during the transcription process and the synthesis of DNA during DNA replication.1 It is generated by the citric acid cycle and provides a source of energy for protein synthesis and gluconeogenesis, activating substrates in metabolic reactions.2 GTP is essential for G protein-related signal transduction in second-messenger mechanisms where it is converted to GDP through the action of GTPases.3
1.Ohta, T., Sarkar, S., and Thach, R.E.The role of guanosine 5'-triphosphate in the initiation of peptide synthesis. III. Binding of formylmethionyl-tRNA to ribosomesProc. Natl. Acad. Sci. USA58(4)1638-1644(1967)
2.Hanson, R.W., and Garber, A.J.Phosphoenolpyruvate carboxykinase. I. Its role in gluconeogenesisAm. J. Clin. Nutr.25(10)1010-1021(1972)
3.Neer, E.J.G proteins: Critical control points for transmembrane signalsProtein Sci.3(1)3-14(1994)
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