Proparacaine盐酸盐是电压门控钠离子通道拮抗剂，ED50为3.4mM。
Proparacaine Hydrochloride is a voltage-gated sodium channels antagonist with ED50 of 3.4 mM.IC50 Value: 3.4 mM(ED50) [1]Target: Sodium Channelin vitro: Proparacaine is more potent and less toxic than cocaine [1]. Proparacaine significantly increases in FHV-1 (P < 0.01), C. felis, and 28S rDNA Ct values when fusidic acid is used [2].in vivo: Proparacaine inhibits corneal epithelial migration and adhesion through alteration of the actin cytoskeleton [3]. Proparacaine acts like bupivacaine or lidocaine and produces dose-related spinal blockades of motor function, proprioception and nociception. Intrathecal proxymetacaine also produces longer sensory blockade than motor blockade [4].
[1]. Grant, R.L. and D. Acosta, Comparative toxicity of tetracaine, proparacaine and cocaine evaluated with primary cultures of rabbit corneal epithelial cells. Exp Eye Res, 1994. 58(4): p. 469-78. [2]. Segarra, S., K. Papasouliotis, and C. Helps, The in vitro effects of proxymetacaine, fluorescein, and fusidic acid on real-time PCR assays used for the diagnosis of Feline herpesvirus 1 and Chlamydophila felis infections. Vet Ophthalmol, 2011. 14 Suppl 1: [3]. Dass, B.A., H.K. Soong, and B. Lee, Effects of proparacaine on actin cytoskeleton of corneal epithelium. J Ocul Pharmacol, 1988. 4(3): p. 187-94. [4]. Hung, C.H., et al., Intrathecal oxybuprocaine and proxymetacaine produced potent and long-lasting spinal anesthesia in rats. Neurosci Lett, 2009. 454(3): p. 249-53.
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