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Biotin-PEG-azide (MW 5000) 是基于 PEG 结构的 PROTAC linker,可以用来制备 PROTAC。
Biotin-PEG-azide (MW 5000) is a PEG-based PROTAC linker can be used in the synthesis of PROTAC[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein[1].
PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.
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